Resveratrol - A comprehensive review of recent advances in anticancer drug design and development

Resveratrol is a natural polyphenolic stilbene isolated from various Plants, foods and beverages with a broad spectrum of biological and pharmacological properties through modulating diverse targets and signaling pathways. Particularly, it has attracted a great deal of attention as a promising and multitarget Anticancer agent due to its potential use in chemoprevention and chemotherapy of various tumors. However, unfavorable pharmacokinetics/pharmacodynamics profile such as poor bioavailability restricted its applications. Therefore, medicinal chemists have synthesized a lot of novel derivatives and analogues of resveratrol using different modification strategies to overcome these limitations and improve Anticancer efficacy. Herein, we reviewed the design, synthesis, structure-activity relationship and mechanism of the most potent and privileged resveratrol-based compounds that showed promising Anticancer activities in the last five years. We classified these compounds into the ten different categories based on their chemical structure similarities.

Anticancer; Antitumor; Chemotherapy; Phytoalexin; Polyphenol; Resveratrol; Stilbenoid.