2. Academic Validation
  3. COVID-19: Drug Targets and Potential Treatments

COVID-19: Drug Targets and Potential Treatments

  • J Med Chem. 2020 Nov 12;63(21):12359-12386. doi: 10.1021/acs.jmedchem.0c00606.
Carmen Gil 1,  Tiziana Ginex 1,  Inés Maestro 1,  Vanesa Nozal 1,  Lucía Barrado-Gil 1,  Miguel Ángel Cuesta-Geijo 1,  Jesús Urquiza 2,  David Ramírez 3,  Covadonga Alonso 2,  Nuria E Campillo 1,  Ana Martinez 1
Affiliations

Affiliations

  • 1 Centro de Investigaciones Biológicas Margarita Salas (CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain.
  • 2 Department of Biotechnology, Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria (INIA), Ctra. de la Coruña km 7.5, 28040 Madrid, Spain.
  • 3 Instituto de Ciencias Biomédicas, Universidad Autónoma de Chile, Llano Subercaseaux 2801- piso 6, 7500912 Santiago, Chile.
PMID: 32511912 DOI: 10.1021/acs.jmedchem.0c00606
Abstract

Currently, humans are immersed in a pandemic caused by the emerging severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which threatens public health worldwide. To date, no drug or vaccine has been approved to treat the severe disease caused by this coronavirus, COVID-19. In this paper, we will focus on the main virus-based and host-based targets that can guide efforts in medicinal chemistry to discover new drugs for this devastating disease. In principle, all CoV Enzymes and proteins involved in viral replication and the control of host cellular machineries are potentially druggable targets in the search for therapeutic options for SARS-CoV-2. This Perspective provides an overview of the main targets from a structural point of view, together with reported therapeutic compounds with activity against SARS-CoV-2 and/or Other CoVs. Also, the role of innate immune response to coronavirus Infection and the related therapeutic options will be presented.

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