2. Academic Validation
  3. Triple-negative breast cancer molecular subtyping and treatment progress

Triple-negative breast cancer molecular subtyping and treatment progress

  • Breast Cancer Res. 2020 Jun 9;22(1):61. doi: 10.1186/s13058-020-01296-5.
Li Yin 1 2 3,  Jiang-Jie Duan 1 2 3,  Xiu-Wu Bian 2 3,  Shi-Cang Yu 4 5 6
Affiliations

Affiliations

  • 1 Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), ChongQing, 400038, China.
  • 2 Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), ChongQing, 400038, China.
  • 3 Key Laboratory of Cancer Immunopathology, Ministry of Education, ChongQing, 400038, China.
  • 4 Department of Stem Cell and Regenerative Medicine, Southwest Hospital, Third Military Medical University (Army Medical University), ChongQing, 400038, China. yushicang@163.com.
  • 5 Institute of Pathology and Southwest Cancer Center, Southwest Hospital, Third Military Medical University (Army Medical University), ChongQing, 400038, China. yushicang@163.com.
  • 6 Key Laboratory of Cancer Immunopathology, Ministry of Education, ChongQing, 400038, China. yushicang@163.com.
PMID: 32517735 DOI: 10.1186/s13058-020-01296-5
Abstract

Triple-negative breast Cancer (TNBC), a specific subtype of breast Cancer that does not express Estrogen Receptor (ER), Progesterone Receptor (PR), or human epidermal growth factor receptor 2 (HER-2), has clinical features that include high invasiveness, high metastatic potential, proneness to relapse, and poor prognosis. Because TNBC tumors lack ER, PR, and HER2 expression, they are not sensitive to endocrine therapy or HER2 treatment, and standardized TNBC treatment regimens are still lacking. Therefore, development of new TNBC treatment strategies has become an urgent clinical need. By summarizing existing treatment regimens, therapeutic drugs, and their efficacy for different TNBC subtypes and reviewing some new preclinical studies and targeted treatment regimens for TNBC, this paper aims to provide new ideas for TNBC treatment.

Keywords

Molecular subtype; Therapeutic regimen; Therapeutic target; Triple-negative breast cancer.

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