2. Academic Validation
  3. The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases

The biological role of arachidonic acid 12-lipoxygenase (ALOX12) in various human diseases

  • Biomed Pharmacother. 2020 Sep;129:110354. doi: 10.1016/j.biopha.2020.110354.
Zhonghua Zheng 1,  Yin Li 1,  Gehui Jin 1,  Tianyi Huang 1,  Mengsha Zou 1,  Shiwei Duan 2
Affiliations

Affiliations

  • 1 Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China.
  • 2 Medical Genetics Center, School of Medicine, Ningbo University, Ningbo, Zhejiang, 315211, China. Electronic address: duanshiwei@nbu.edu.cn.
PMID: 32540644 DOI: 10.1016/j.biopha.2020.110354
Abstract

ALOX12 encodes arachidonic acid 12-lipoxygenase that acts on different polyunsaturated fatty acid substrates to produce biologically active lipid mediators including eicosanes and lipoxins. ALOX12 protein plays an important role in inflammation and oxidation, while abnormal DNA methylation and genetic variants of ALOX12 are associated with various human diseases and pathological phenotypes, such as Cardiovascular Disease, diabetes, neurodegenerative diseases, respiratory system disease, Cancer, Infection, etc. Here, this article reviews the mechanisms by which ALOX12 participates in related diseases, which will provide systematic knowledge for future ALOX12 related studies.

Keywords

Arachidonate 12-lipoxygenase; Diseases; Inflammation; Single nucleotide polymorphism.

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