2. Academic Validation
  3. Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures

Highly Modified Lanostane Triterpenes from the Wood-Rot Basidiomycete Ganoderma colossus: Comparative Chemical Investigations of Natural and Artificially Cultivated Fruiting Bodies and Mycelial Cultures

  • J Nat Prod. 2020 Jul 24;83(7):2066-2075. doi: 10.1021/acs.jnatprod.9b00947.
Masahiko Isaka 1,  Panida Chinthanom 1,  Rattaket Choeyklin 1,  Tuksaporn Thummarukcharoen 2,  Pranee Rachtawee 1,  Malipan Sappan 1,  Kitlada Srichomthong 1,  Ryoma Fujii 3,  Kyohei Kawashima 3,  Seiji Mori 3
Affiliations

Affiliations

  • 1 National Center for Genetic Engineering and Biotechnology (BIOTEC), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
  • 2 National Biobank of Thailand (NBT), 113 Thailand Science Park, Phaholyothin Road, Klong Luang, Pathumthani 12120, Thailand.
  • 3 Institute of Quantum Beam Science, Ibaraki University, Mito 310-8512, Japan.
PMID: 32639735 DOI: 10.1021/acs.jnatprod.9b00947
Abstract

The wood-rot basidiomycete Ganoderma colossus has been chemically investigated. Comparative analyses of the natural fruiting body, artificially cultivated fruiting bodies, and mycelial cultures resulted in the isolation, in total, of 13 new highly modified lanostanes, ganocolossusins A-H (1-8) and ganodermalactones T-X (9-13), together with 23 known compounds (14-36). There were significant overlaps of the same compounds among the three different states of the fungal Materials. Ganocolossusin D (4) displayed the most potent antimalarial activity against Plasmodium falciparum K1 (multi-drug-resistant strain) with an IC50 value of 2.4 μM, while it was noncytotoxic to Vero cells at 50 μg/mL.

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