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  3. Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review

Recent developments of gallic acid derivatives and their hybrids in medicinal chemistry: A review

  • Eur J Med Chem. 2020 Oct 15:204:112609. doi: 10.1016/j.ejmech.2020.112609.
Nourah A Al Zahrani 1,  Reda M El-Shishtawy 2,  Abdullah M Asiri 3
Affiliations

Affiliations

  • 1 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Chemistry Department, Faculty of Science, University of Jeddah, Jeddah, Saudi Arabia.
  • 2 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Dyeing, Printing and Textile Auxiliaries Department, Textile Research Division, National Research Centre, Dokki, Cairo, Egypt. Electronic address: elshishtawy@hotmail.com.
  • 3 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia; Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
PMID: 32731188 DOI: 10.1016/j.ejmech.2020.112609
Abstract

The leading cause of several degenerative diseases such as atherosclerosis, Cancer, aging, cardiovascular, and inflammatory diseases is oxidative stress, a consequence of overproduction and accumulation of free radicals. Naturally occurring Antioxidants polyphenols have unnumbered biological activities such as Antibacterial, Anticancer, Antiviral, Antifungal, anticholesterol, and antiulcer. A naturally occurring gallic acid (3,4,5-trihydroxybenzoic acid), is highly antioxidant and may play a protective role in healthy individuals by inhibiting Apoptosis. Pharmacological agents containing gallic acid and of diverse therapeutic categories as Antioxidants, Anticancer, antimicrobial, chondro-protective effect, Carbonic Anhydrase inhibitors, antidiabetic activity, anti-ulcerogenic, Cathepsin D Inhibitor, etc. have made this nucleus as an indispensable anchor for designing and development of new pharmacological agents. This review is an update on the latest development of the chemistry and the medicinal impacts of pharmacophores containing gallic acids. In addition, fused gallic acid derivatives and hybrid molecules containing different bioactive moieties in the presence of gallic acid are also presented and discussed.

Keywords

Gallic acid; Hybrid molecules; Ionic gallate; Medicinal impact.

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