2. Academic Validation
  3. Heterogeneous Responses to Mechanical Force of Prostate Cancer Cells Inducing Different Metastasis Patterns

Heterogeneous Responses to Mechanical Force of Prostate Cancer Cells Inducing Different Metastasis Patterns

  • Adv Sci (Weinh). 2020 Jun 17;7(15):1903583. doi: 10.1002/advs.201903583.
Zhixiao Liu 1 2,  Liujun Wang 1,  Huan Xu 3 4,  Qiqige Du 5,  Li Li 1,  Ling Wang 6 7,  En Song Zhang 5,  Guosong Chen 5,  Yue Wang 1 6 7
Affiliations

Affiliations

  • 1 Research Center of Developmental Biology Department of Histology and Embryology College of Basic Medicine Second Military Medical University Shanghai 200433 China.
  • 2 Department of Urology Shanghai General Hospital Shanghai Jiao Tong University School of Medicine Shanghai 201620 China.
  • 3 Department of Urology Changhai Hospital of Shanghai Second Military Medical University Shanghai 200433 China.
  • 4 Department of Pathology Duke University School of Medicine Durham NC 27710 USA.
  • 5 The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan University Shanghai 200433 China.
  • 6 Stem Cell and Regeneration Medicine Institute Research Center of Translational Medicine Second Military Medical University Shanghai 200433 China.
  • 7 Shanghai Key Laboratory of Cell Engineering Second Military Medical University Shanghai 200433 China.
PMID: 32775149 DOI: 10.1002/advs.201903583
Abstract

The physical cues in the extracellular environment play important roles in Cancer cell metastasis. However, how metastatic Cancer cells respond to the diverse mechanical environments of metastatic sites is not fully understood. Here, substrates with different mechanical properties are prepared to simulate the extracellular mechanical environment of various human tissues. The prostate Cancer (PC) cells derived from different Cancer metastasis sites show heterogeneity in mechanical response. This heterogeneity mediates two distinct metastasis patterns. High stiffness promotes individual cell migration and proliferation by inducing Yes-associated protein and tafazzin (YAP/TAZ) nuclear localization in bone metastasis-derived cells, whereas low stiffness promotes cell migration and proliferation by inducing lymphatic metastasis-derived cells to form clusters characterized by high expression of CD44. The different metastasis patterns induced by the mechanical properties of the extracellular environment are crucial in the development of PC.

Keywords

extracellular microenvironment; mechanical force response heterogeneity; physical cues; prostate cancer metastasis.

Figures
Products