2. Academic Validation
  3. Heimiomycins A-C and Calamenens from the African Basidiomycete Heimiomyces sp

Heimiomycins A-C and Calamenens from the African Basidiomycete Heimiomyces sp

  • J Nat Prod. 2020 Aug 28;83(8):2501-2507. doi: 10.1021/acs.jnatprod.0c00486.
Tian Cheng 1 2,  Clara Chepkirui 1 2,  Cony Decock 3,  Josphat C Matasyoh 4,  Marc Stadler 1 2
Affiliations

Affiliations

  • 1 Department of Microbial Drugs, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124 Braunschweig, Germany.
  • 2 German Centre for Infection Research (DZIF), partner site Hannover-Braunschweig, 38124 Braunschweig, Germany.
  • 3 Mycothéque de l'Universite Catholique de Louvain (BCCM/MUCL), Place Croix du Sud 3, B-1348 Louvain-la-Neuve, Belgium.
  • 4 Department of Chemistry, Faculty of Sciences, Egerton University, P.O. Box 536, 20115, Njoro, Kenya.
PMID: 32786884 DOI: 10.1021/acs.jnatprod.0c00486
Abstract

Three previously undescribed compounds named heimiomycin A-C (1-3), featuring a unique scaffold with calamenene connected to a hydroxystyryl-pyranone moiety, along with the new calamenene derivatives 4 and 5 and phenanthridine derivative (6) were obtained from a culture of a Heimiomyces sp. This is the first report of the occurrence of calamenene-type Terpenoids in fungi. Compound 3 exhibited antimicrobial activity against Gram-positive bacteria and Mucor hiemalis. Compounds 1 and 3 displayed moderate cytotoxicity against KB 3.1 and L929 cell lines, respectively.

Figures