1. Academic Validation
  2. Bioactive Alkaloids from the Actinomycete Actinoalloteichus sp. ZZ1866

Bioactive Alkaloids from the Actinomycete Actinoalloteichus sp. ZZ1866

  • J Nat Prod. 2020 Sep 25;83(9):2686-2695. doi: 10.1021/acs.jnatprod.0c00588.
Le Qin 1 Wenwen Yi 1 Xiao-Yuan Lian 2 Zhizhen Zhang 1
Affiliations

Affiliations

  • 1 Ocean College, Zhoushan Campus, Zhejiang University, Zhoushan 316021, People's Republic of China.
  • 2 College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China.
Abstract

The new Alkaloids marinacarbolines E-Q (1-10, 12-14), caerulomycin N (15), and actinoallonaphthyridine A (16), together with the known marinacarboline C (11) and cyanogramide (17), were isolated from the actinomycete Actinoalloteichus sp. ZZ1866. The structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, Mosher's method, ECD calculations, single-crystal X-ray diffraction analysis, and chemical degradation studies. Marinacarbolines E-L (1-8) share an indole-pyridone-imidazole tetracyclic skeleton, which is the first example of this kind of skeleton. Caerulomycin N (15) and cyanogramide (17) exhibited cytotoxic activity against both human glioma U251 and U87MG cells with IC50 values of 2.0-7.2 μM. Marinacarbolines E (1), G (3), I (5), and M (9) showed cytotoxic activity against U87MG cells with IC50 values of 2.3-8.9 μM.

Figures