2. Academic Validation
  3. Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa

Uncommon terpenoids with anti-inflammatory activity from the Hainan soft coral Sinularia tumulosa

  • Bioorg Chem. 2020 Nov;104:104167. doi: 10.1016/j.bioorg.2020.104167.
You-Sheng Cai 1,  Wan-Xiang Cui 2,  Wei Tang 2,  Yue-Wei Guo 3
Affiliations

Affiliations

  • 1 Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China.
  • 2 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
  • 3 State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555, Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China. Electronic address: ywguo@simm.ac.cn.
PMID: 32920351 DOI: 10.1016/j.bioorg.2020.104167
Abstract

One novel sesquiterpenoid containing an unprecedented eight-membered cyclic peroxide motif, sinulatumolin A (1), along with four new related Terpenoids, namely sinulatumolins B-E (2-4 and 6), were isolated from South China Sea soft coral Sinularia tumulosa. The structures of all the isolates were elucidated by detailed spectroscopic analysis, chemical transformations, and single X-ray diffraction analysis. Compound 1 represents the first example of sesquiterpene bearing an eight-membered cyclic peroxide ring from soft coral. All the new compounds isolated were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4 and 6 displayed significant TNF-α inhibitory activity being comparable with that of the positive control dexamethasone (IC50 = 8.7 μM), with IC50 values of 7.5, 2.6, 5.5, and 3.6 μM, respectively.

Keywords

Anti-inflammatory activity; Peroxide; Sinularia tumulosa; Terpenoids.

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