2. Academic Validation
  3. Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations

Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations

  • Int J Endocrinol. 2020 Sep 10:2020:3236828. doi: 10.1155/2020/3236828.
Jingbo Xie 1,  Jian Guo 2,  Zaeema Kanwal 3,  Mingzheng Wu 4,  Xiangyang Lv 5,  Nihal Abdalla Ibrahim 6,  Ping Li 7,  Manal Ali Buabeid 6,  El-Shaimaa A Arafa 6,  Qingshan Sun 8
Affiliations

Affiliations

  • 1 Department of Orthopedics, Fengcheng People's Hospital, Fengcheng, Jiangxi 331100, China.
  • 2 Department of the Second Orthopedics, Hongdu Hospital of Traditional Chinese Medicine Affiliated to Jiangxi University of Traditional Chinese Medicine, Nanchang Hongdu Traditional Chinese Medicine Hospital, Nanchang, Jiangxi 330008, China.
  • 3 Ameer Ud Din Medical College, Lahore, Pakistan.
  • 4 Department of Orthopaedics, Pu'ai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430000, China.
  • 5 Department of Orthopaedics, Xi'an International Medical Center Hospital, Xi'an, Shaanxi 710100, China.
  • 6 Department of Clinical Sciences, Ajman University, Ajman 346, UAE.
  • 7 Department of Orthopaedics, Ya'an People's Hospital, Ya'an, Sichuan 625000, China.
  • 8 Department of Orthopedics, The Third Hospital of Shandong Province, Jinan, Shandong 250031, China.
PMID: 32963524 DOI: 10.1155/2020/3236828
Abstract

Calcitonin was discovered as a peptide hormone that was known to reduce the calcium levels in the systemic circulation. This hypocalcemic effect is produced due to multiple reasons such as inhibition of bone resorption or suppression of calcium release from the bone. Thus, Calcitonin was said as a primary regulator of the bone resorption process. This is the reason why Calcitonin has been used widely in clinics for the treatment of bone disorders such as osteoporosis, hypercalcemia, and Paget's disease. However, presently Calcitonin usage is declined due to the development of efficacious formulations of new drugs. Calcitonin gene-related Peptides and several other Peptides such as intermedin, amylin, and Adrenomedullin (ADM) are categorized in Calcitonin family. These Peptides are known for the structural similarity with Calcitonin. Aside from having a similar structure, these Peptides have few overlapping biological activities and signal transduction action through related receptors. However, several Other activities are also present that are peptide specific. In vitro and in vivo studies documented the posttreatment effects of Calcitonin peptides, i.e., positive effect on bone osteoblasts and their formation and negative effect on osteoclasts and their resorption. The recent research studies carried out on genetically modified mice showed the inhibition of osteoclast activity by amylin, while astonishingly Calcitonin plays its role by suppressing osteoblast and bone turnover. This article describes the review of the bone, the activity of the Calcitonin family of Peptides, and the link between them.

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