Cytotoxic Xanthone Derivatives from the Mangrove-Derived Endophytic Fungus Peniophora incarnata Z4

J Nat Prod. 2020 Oct 23;83(10):2976-2982. doi: 10.1021/acs.jnatprod.0c00523.

Sui Jun Li ¹, Fang Wen Jiao ¹, Wei Li ¹, Xuan Zhang ¹, Wei Yan ², Rui Hua Jiao ¹

Affiliations

1 State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Nanjing University, Nanjing 210023, China.
2 State & Local Joint Engineering Research Center of Green Pesticide Invention and Application, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China.

PMID: 32975117 DOI: 10.1021/acs.jnatprod.0c00523

Abstract

The mangrove-derived endophytic fungus Peniophora incarnata Z4 produced seven new xanthone derivatives, including four new tetrahydroxanthones (1-4), one new chromone (5), one new xanthone (6), and one new xanthone dimer (7), together with one known compound, globosuxanthone B (8). Their structures were determined by an extensive analysis of 1D and 2D NMR, HRESIMS, ECD, and single-crystal X-ray diffraction data. In cytotoxic activity assays, compound 2 showed cytotoxicity against three carcinoma cell lines with IC₅₀ values less than 10 μM.

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