2. Academic Validation
  3. Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from Daphne odora

  • J Nat Prod. 2020 Nov 25;83(11):3270-3277. doi: 10.1021/acs.jnatprod.0c00540.
Kouharu Otsuki 1,  Wei Li 1,  Kasumi Miura 1,  Yoshihisa Asada 1,  Li Huang 2,  Chin-Ho Chen 2,  Kuo-Hsiung Lee 3 4,  Kazuo Koike 1
Affiliations

Affiliations

  • 1 Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba 274-8510, Japan.
  • 2 Surgical Science, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, United States.
  • 3 Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
  • 4 Chinese Medicine Research and Development Center, China Medical University and Hospital, Taichung 404, Taiwan.
PMID: 32997496 DOI: 10.1021/acs.jnatprod.0c00540
Abstract

Five new [daphneodorins D-H (1, 5, and 10-12)] and seven known daphnane Diterpenoids (2-4 and 6-9) were isolated from Daphne odora. The structures of the new compounds were elucidated by extensive physicochemical and spectroscopic analysis. The isolated compounds were evaluated for their anti-HIV activity against HIV-1 Infection of MT4 cells. Nine daphnane diterpenoid orthoesters (1-9) showed potent anti-HIV activity with EC50 values of 1.5-7.7 nM.

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