2. Academic Validation
  3. An Organelle-Specific Nanozyme for Diabetes Care in Genetically or Diet-Induced Models

An Organelle-Specific Nanozyme for Diabetes Care in Genetically or Diet-Induced Models

  • Adv Mater. 2020 Nov;32(45):e2003708. doi: 10.1002/adma.202003708.
Yanfeng Zhou 1,  Chang Liu 2,  Yun Yu 2,  Min Yin 3,  Jinli Sun 1,  Jing Huang 4,  Nan Chen 3,  Hui Wang 1,  Chunhai Fan 5,  Haiyun Song 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
  • 2 Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
  • 3 College of Chemistry and Materials Science, Shanghai Normal University, Shanghai, 200234, China.
  • 4 Department of Neurology, Xuhui District Central Hospital, Shanghai, 200032, China.
  • 5 School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, and Shanghai Key Laboratory for Nucleic Acids Chemistry and Nanomedicine, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200240, China.
PMID: 33015921 DOI: 10.1002/adma.202003708
Abstract

The development of nanozymes has made active impact in diagnosis and therapeutics. However, understanding of the full effects of these nanozymes on biochemical pathways and metabolic homeostasis remains elusive. Here, it is found that iron oxide nanoparticles (Fe3 O4 NPs), a type of well-established nanozyme, can locally regulate the energy sensor adenosine 5'-monophosphate-activated protein kinase (AMPK) via their peroxidase-like activity in the acidic lysosomal compartment, thereby promoting glucose metabolism and Insulin response. Fe3 O4 NPs induce AMPK activation and enhance glucose uptake in a variety of metabolically active cells as well as in Insulin resistant cell models. Dietary Fe3 O4 NPs display therapeutic effects on hyperglycemia and hyperinsulinemia in Drosophila models of diabetes induced by genetic manipulation or high-sugar diet. More importantly, intraperitoneal administration of Fe3 O4 NPs stimulates AMPK activities in metabolic tissues, reduces blood glucose levels, and improves glucose tolerance and Insulin sensitivity in diabetic ob/ob mice. The study reveals intrinsic organelle-specific properties of Fe3 O4 NPs in AMPK activation, glycemic control, and insulin-resistance improvement, suggesting their potential efficacy in diabetes care.

Keywords

AMPK; diabetes; insulin resistance; iron oxide nanoparticles; nanozymes.

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