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  3. A brief overview on recent advances in spiro[chromane-2,4'-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

A brief overview on recent advances in spiro[chromane-2,4'-piperidine]-4(3H)-one-functionalized compounds in medicinal chemistry research

  • Bioorg Med Chem. 2020 Dec 1;28(23):115813. doi: 10.1016/j.bmc.2020.115813.
Nitin G Ghatpande 1,  Jagannath S Jadhav 2,  Rajshekhar V Kaproormath 3,  Mahmoud E Soliman 4,  Mahidansha M Shaikh 5
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa; Unique Med Chem Laboratories, L-64, Chincholli MIDC, Solapur 413255, M.S., India.
  • 2 Department of Chemistry, Shivaji University, Kolhapur 416004, M.S., India.
  • 3 Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa. Electronic address: karpoormath@ukzn.ac.za.
  • 4 Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa.
  • 5 Department of Pharmaceutical Chemistry, School of Health Science, University of KwaZulu-Natal, Durban 4041, South Africa; Unique Med Chem Laboratories, L-64, Chincholli MIDC, Solapur 413255, M.S., India. Electronic address: shaiksm@ukzn.ac.za.
PMID: 33069128 DOI: 10.1016/j.bmc.2020.115813
Abstract

The spiro[chromane-2,4'-piperidine]-4(3H)-one is an important pharmacophore. It is a structural component in many drugs, drug candidates (or lead compounds) and various biochemical reagents. This review demonstrated an impressive progress in syntheses of spiro[chromane-2,4'-piperidine]-4(3H)-one-derived compoundsin the recent years and focuses on features of their biological relevance's. The prospects for the development of new biologically active substances containing a spiro[chromane-2,4'-piperidine]-4(3H)-one pharmacophore are analyzed and briefly discussed in terms of its structure, reaction, mechanism, scope and potential utility.

Keywords

4′-piperidine]-4(3H)-one; Biological activity; Pharmacophores; Spiro[chromane-2; structure activity relationship (SAR).

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