2. Academic Validation
  3. Resveratrol rescued the pain related hypersensitivity for Cntnap2-deficient mice

Resveratrol rescued the pain related hypersensitivity for Cntnap2-deficient mice

  • Eur J Pharmacol. 2021 Jan 15;891:173704. doi: 10.1016/j.ejphar.2020.173704.
Zaiqi Zhang 1,  Zhiyong Yao 2,  Kunyang Wu 3,  Ti Zhang 2,  Chaoqun Xing 4,  Xiao-Liang Xing 5
Affiliations

Affiliations

  • 1 Hunan Provincial Key Laboratory for Dong Medicine, Hunan University of Medicine, Huaihua 418000, Hunan, PR China.
  • 2 Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, Hunan University of Medicine, Huaihua 418000, Hunan, PR China.
  • 3 Zhejiang Center for Disease Control and Prevention, Hangzhou 310000, Zhejiang, PR China.
  • 4 The First Affiliated Hospital of Hunan University of Medicine, Huaihua 418000, Hunan, PR China. Electronic address: 1191375604@qq.com.
  • 5 Hunan Provincial Key Laboratory for Dong Medicine, Hunan University of Medicine, Huaihua 418000, Hunan, PR China; Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, Hunan University of Medicine, Huaihua 418000, Hunan, PR China. Electronic address: 283110983@qq.com.
PMID: 33137333 DOI: 10.1016/j.ejphar.2020.173704
Abstract

Contactin-associated protein-like 2 (CNTNAP2 or CASPR2) is a neuronal transmembrane protein of the neurexin superfamily which is correlated with pain related hypersensitivity. Recent results indicated that the hyperactive phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) signaling pathway may be a promising therapeutic target for pain-related hypersensitivity in patients with dysfunction of CNTNAP2. Resveratrol is one of the most widely studied Polyphenols with several beneficial properties. In the present study, we investigated the effects of resveratrol on the pain related hypersensitivity. And we found that the up-regulated phosphorylation of S6 could be suppressed by resveratrol. The nocifensive behavior duration time to heat and chemical algogens stimulation in Cntnap2-deficiency (Cntnap2-/-) mice could be attenuated by resveratrol. Our results indicated that resveratrol could rescue the pain related hypersensitivity for Cntnap2-/- mice may be via mTOR signaling pathway.

Keywords

Pain hypersensitivity; Resveratrol; mTOR.

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