2. Academic Validation
  3. Antimalarial application of quinones: A recent update

Antimalarial application of quinones: A recent update

  • Eur J Med Chem. 2021 Jan 15:210:113084. doi: 10.1016/j.ejmech.2020.113084.
Om P S Patel 1,  Richard M Beteck 2,  Lesetja J Legoabe 3
Affiliations

Affiliations

  • 1 Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. Electronic address: ompspatelcdri@gmail.com.
  • 2 Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa.
  • 3 Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom, 2520, South Africa. Electronic address: lesetja.legoabe@nwu.ac.za.
PMID: 33333397 DOI: 10.1016/j.ejmech.2020.113084
Abstract

Atovaquone belongs to a naphthoquinone class of drugs and is used in combination with proguanil (Malarone) for the treatment of acute, uncomplicated malaria caused by Plasmodium falciparum (including chloroquine-resistant P. falciparum/P. vivax). Numerous quinone-derived compounds have attracted considerable attention in the last few decades due to their potential in antimalarial drug discovery. Several semi-synthetic derivatives of natural Quinones, synthetic Quinones (naphtho-/benzo-quinone, Anthraquinones, thiazinoquinones), and quinone-based hybrids were explored for their in vitro and in vivo antimalarial activities. A careful literature survey revealed that this topic has not been compiled as a review article so far. Therefore, we herein summarise the recent discovery (the year 2009-2020) of quinone based antimalarial compounds in chronological order. This compilation would be very useful towards the exploration of novel quinone-derived compounds against malarial parasites with promising efficacy and lesser side effects.

Keywords

Anthraquinones; Malaria; Naphtho-/benzo-quinones; Natural and semi-synthetic quinones; Quinone hybrids; Thiazinoquinones.

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