2. Academic Validation
  3. LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma

LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma

  • Biomed Pharmacother. 2021 Jan;133:111023. doi: 10.1016/j.biopha.2020.111023.
Jia-Qi Sheng 1,  Mu-Ru Wang 2,  Dan Fang 3,  Lian Liu 4,  Wen-Jie Huang 5,  De-An Tian 6,  Xing-Xing He 7,  Pei-Yuan Li 8
Affiliations

Affiliations

  • 1 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: 936084969@qq.com.
  • 2 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: 906074661@qq.com.
  • 3 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: 2860778477@qq.com.
  • 4 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: 774097792@qq.com.
  • 5 Hepatic Surgery Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Clinical Medical Research Center of Hepatic Surgery at Hubei Province, Wuhan, China. Electronic address: huangwenjie@tjh.tjmu.edu.cn.
  • 6 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: datian@tjh.tjmu.edu.cn.
  • 7 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: xxhe@tjh.tjmu.edu.cn.
  • 8 Division of Gastroenterology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Electronic address: pyli@tjh.tjmu.edu.cn.
PMID: 33378941 DOI: 10.1016/j.biopha.2020.111023
Abstract

Long noncoding RNAs (lncRNAs) have been identified to play increasingly important roles in tumorigenesis, and they may serve as novel biomarkers for Cancer therapy. LncRNA NBR2 (neighbor of BRCA1 gene 2), a novel identified lncRNA, is demonstrated to decrease in several cancers. However, it is still unknown whether lncRNA NBR2 is involved in hepatocellular carcinoma and Autophagy. We found that HCC cases with lower NBR2 expression had significantly worse overall survival than those with higher NBR2 expression in advanced patients. And the expression of NBR2 was negatively correlated with the degree of malignancy of HCC cell lines and differentiation of hepatocellular carcinoma. Besides, NBR2 inhibited the proliferation, invasion, and migration of liver Cancer cells. We further found that NBR2 repressed cytoprotective Autophagy to restrain HCC cell proliferation. Moreover, NBR2 inhibited Beclin 1-dependent Autophagy through ERK and JNK pathways. Taken together, NBR2 suppressed autophagy-induced cell proliferation at least partly through ERK and JNK pathways. These data indicated that NBR2 served as a tumor suppressor gene in hepatocellular carcinoma. The current study provides a novel insight and treatment strategy for hepatocellular carcinoma.

Keywords

Autophagy; Hepatocellular carcinoma; Long noncoding RNA; NBR2; Tumorigenesis.

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