2. Academic Validation
  3. Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production

Diterpenoids and Diacetylenes from the Roots of Aralia cordata with Inhibitory Effects on Nitric Oxide Production

  • J Nat Prod. 2021 Feb 26;84(2):230-238. doi: 10.1021/acs.jnatprod.0c00842.
Jun Gu Kim 1,  Jin Woo Lee 1,  Thi Phuong Linh Le 1,  Jae Sang Han 1,  Haeun Kwon 2,  Dongho Lee 2,  Jin Tae Hong 1,  Youngsoo Kim 1,  Mi Kyeong Lee 1,  Bang Yeon Hwang 1
Affiliations

Affiliations

  • 1 College of Pharmacy, Chungbuk National University, Cheongju 28160, Korea.
  • 2 Department of Plant Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul 02841, Korea.
PMID: 33476145 DOI: 10.1021/acs.jnatprod.0c00842
Abstract

Bioactivity-guided isolation of a MeOH extract of Aralia cordata led to the isolation of four new ent-pimarane Diterpenoids (1-4) and a diacetylene (5) together with 21 known compounds (6-26). Their structures were established based on the interpretation of one- and two-dimensional NMR and HRESIMS data. The absolute configurations of the new isolates were determined by electronic circular dichroism data analysis, single crystal X-ray diffraction, and Mosher's esterification method. All compounds exhibited inhibitory effects on lipopolysaccharide-induced nitric oxide production in RAW 264.7 macrophages with IC50 values ranging from 1.1 to 69.4 μM.

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