2. Academic Validation
  3. ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

ID1 inhibits foot-and-mouth disease virus replication via targeting of interferon pathways

  • FEBS J. 2021 Jul;288(14):4364-4381. doi: 10.1111/febs.15725.
Tingting Ren 1 2,  Haotai Chen 1 2,  Xinsheng Liu 1 2,  Yanxue Wang 1 2,  Aixia Fan 1 2,  Linlin Qi 1 2,  Li Pan 1 2,  Wenlong Bai 3 4,  Yongguang Zhang 1 2,  Yuefeng Sun 1 2
Affiliations

Affiliations

  • 1 State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China.
  • 2 Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, China.
  • 3 The Departments of Pathology and Cell Biology, Oncological Sciences, University of South Florida College of Medicine, Tampa, FL, USA.
  • 4 Programs of Cancer Biology & Evolution, H. Lee Moffitt Cancer Center, Tampa, FL, USA.
PMID: 33492759 DOI: 10.1111/febs.15725
Abstract

Inhibitor of DNA-binding 1 (ID1) protein has been studied intensively for its functions in tumorigenesis and maintenance of stem cell-like properties, but its roles in virus Infection are less understood. In the present study, we have clearly shown that the foot-and-mouth disease virus (FMDV) promotes ID1 degradation via Cdh1-mediated ubiquitination to facilitate its replication. Mechanistic investigations reveal Forkhead Box O1 (FOXO1) as an ID1 partner, which suppresses interferon regulatory factors 3 expression and interferon (IFN) production. Further investigation identified that ID1 suppresses FOXO1 transcription activity through HDAC4-mediated deacetylation, promoting IFN production and Antiviral immune response. These studies establish a prominent role for ID1 in suppressing FDMV replication, which may be extended to other viruses.

Keywords

ID1; deacetylation; foot-and-mouth disease virus; interferon; ubiquitination.

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