2. Academic Validation
  3. FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application

FDA-approved pyrimidine-fused bicyclic heterocycles for cancer therapy: Synthesis and clinical application

  • Eur J Med Chem. 2021 Mar 15:214:113218. doi: 10.1016/j.ejmech.2021.113218.
Shuai Wang 1,  Xiao-Han Yuan 1,  Sai-Qi Wang 2,  Wen Zhao 1,  Xiao-Bing Chen 2,  Bin Yu 3
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, PR China.
  • 2 Department of Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Henan Cancer Institute, NO.127, Dongming Road, Zhengzhou, 450008, PR China.
  • 3 School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou, 450001, PR China. Electronic address: yubin@zzu.edu.cn.
PMID: 33540357 DOI: 10.1016/j.ejmech.2021.113218
Abstract

Considerable progress has been made in the development of Anticancer agents over the past few decades, and a lot of new Anticancer agents from natural and synthetic sources have been produced. Among heterocyclic compounds, pyrimidine-fused bicyclic heterocycles possess a variety of biological activities such as Anticancer, Antiviral, etc. To date, 147 pyrimidine-fused bicyclic heterocycles have been approved for clinical assessment or are currently being used in clinic, 57 of which have been approved by FDA for clinical treatment of various diseases, and 22 of them are being used in the clinic for the treatment of different cancers. As the potentially privileged scaffolds, pyrimidine-fused bicyclic heterocycles may be used to discover new drugs with similar biological targets and improved therapeutic efficacy. This review aims to provide an overview of the Anticancer applications and synthetic routes of 22 approved pyrimidine-fused bicyclic heterocyclic drugs in clinic.

Keywords

Cancer therapy; Chemical synthesis; Pyrimidine-fused bicyclic heterocycles.

Figures