2. Academic Validation
  3. Targeting SHP2 as a therapeutic strategy for inflammatory diseases

Targeting SHP2 as a therapeutic strategy for inflammatory diseases

  • Eur J Med Chem. 2021 Mar 15:214:113264. doi: 10.1016/j.ejmech.2021.113264.
Yang Liu 1,  Xiaohe Yang 1,  Yali Wang 1,  Yueying Yang 1,  Dejuan Sun 2,  Hua Li 3,  Lixia Chen 4
Affiliations

Affiliations

  • 1 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China.
  • 2 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: 760633805@qq.com.
  • 3 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Electronic address: li_hua@hust.edu.cn.
  • 4 Wuya College of Innovation, Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, China. Electronic address: syzyclx@163.com.
PMID: 33582386 DOI: 10.1016/j.ejmech.2021.113264
Abstract

With the change of lifestyle and the acceleration of aging process, inflammatory diseases have increasingly become one of the most vital threats to global human health. SHP2 protein is a non-receptor tyrosine Phosphatase encoded by PTPN11 gene, and it is widely expressed in various tissues and cells. Numerous studies have shown that SHP2 plays important roles in the regulation of inflammatory diseases, including cancer-related inflammation, neurodegenerative diseases and metabolic diseases. In this paper, the roles of SHP2 in inflammatory diseases of various physiological systems were reviewed. At the same time, the latest SHP2 inhibitors were summarized, which will hold a promise for the therapeutic potential in future.

Keywords

Cancer; Inflammation; SHP2; SHP2 inhibitors.

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