2. Academic Validation
  3. Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine

Relative bioavailability of the hydrochloride, sulphate and ethyl carbonate salts of quinine

  • Br J Clin Pharmacol. 1988 Feb;25(2):261-3. doi: 10.1111/j.1365-2125.1988.tb03299.x.
A Jamaludin 1,  M Mohamad,  V Navaratnam,  K Selliah,  S C Tan,  W H Wernsdorfer,  K H Yuen
Affiliations

Affiliation

  • 1 National Drug Research Centre, Universiti Sains Malaysia, Penang.
PMID: 3358888 DOI: 10.1111/j.1365-2125.1988.tb03299.x
Abstract

The hydrochloride, sulphate and ethylcarbonate salts of quinine were given in single oral doses (600 mg base equivalent) to nine healthy male subjects according to a cross-over design. No statistically significant differences were noted in the plasma drug concentration-time profiles although inter- and intra-subject variation in AUC, Cmax and tmax values was appreciable. The ethylcarbonate salt may be preferred for use in paediatric patients because of its neutral taste.

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  • HY-B1401
    Anti-Plasmodium falciparum Agent