2. Academic Validation
  3. Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition

Anticancer potential of spirocompounds in medicinal chemistry: A pentennial expedition

  • Eur J Med Chem. 2021 Apr 5:215:113263. doi: 10.1016/j.ejmech.2021.113263.
Darshana Bora 1,  Anjali Kaushal 1,  Nagula Shankaraiah 2
Affiliations

Affiliations

  • 1 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India.
  • 2 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Hyderabad, 500037, India. Electronic address: shankar@niperhyd.ac.in.
PMID: 33601313 DOI: 10.1016/j.ejmech.2021.113263
Abstract

Spirocompounds constitute an important class of organic frameworks enveloping numerous pharmacological activities, among them, the promising Anticancer potential of spirocompounds have enthused medicinal chemists to explore new spiro derivatives with significantly improved pharmacodynamic and pharmacokinetic profile along with their mechanism of action. The current review intends to provide a sketch of the Anticancer activity of various spirocompounds like spirooxindole, spiroisoxazole, spiroindole etc, from the past five years unfolding various aspects of pharmacological activities and their structure-activity relationships (SARs). This literature analysis may provide future direction for the efficient design of novel spiromolecules with enhanced safety and efficacy.

Keywords

Anticancer agents; Cytotoxicity; Spirocompound; Spiroisoxazoles; Spiroxindoles.

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