2. Academic Validation
  3. Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

Design, synthesis and bioactivity evaluation of novel pyrazole linked phenylthiazole derivatives in context of antibacterial activity

  • Bioorg Med Chem Lett. 2021 May 1:39:127853. doi: 10.1016/j.bmcl.2021.127853.
Bhautikkumar Patel 1,  Matthew Zunk 2,  Gary Grant 2,  Santosh Rudrawar 3
Affiliations

Affiliations

  • 1 School of Pharmacy and Pharmacology, Griffith University, Gold Coast, QLD 4222, Australia.
  • 2 School of Pharmacy and Pharmacology, Griffith University, Gold Coast, QLD 4222, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia.
  • 3 School of Pharmacy and Pharmacology, Griffith University, Gold Coast, QLD 4222, Australia; Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia. Electronic address: s.rudrawar@griffith.edu.au.
PMID: 33609657 DOI: 10.1016/j.bmcl.2021.127853
Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) infections are a significant burden both clinically and economically worldwide. Increasing resistance to current Antibiotics requires an urgent investigation into novel classes of antimicrobial agents. This study presents a structure-activity relationship (SAR) rationale for pyrazole linked phenylthiazole analogues as new Antibacterial agents. A library of 23 novel pyrazole linked phenylthiazole compounds were synthesised, followed by screening for antimicrobial activity against five Bacterial species and two fungi. The most active compound 14b has shown promising Antibacterial activity against the Gram-positive methicillin-resistant Staphylococcus aureus (MRSA, ATCC 43300) strain (MIC 4 μg/mL). Furthermore, the active pyrazole linked phenylthiazole compound exhibited a better toxicity profile than standard Antibiotics. In summary, these results demonstrate that a pyrazole linked phenylthiazole scaffold has potential as a lead for further investigation to afford novel Antibacterial agents.

Keywords

Anti-infective agents; MRSA resistance; Phenylthiazole; Pyrazole.

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