2. Academic Validation
  3. Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer

Oxygen and oxaliplatin-loaded nanoparticles combined with photo-sonodynamic inducing enhanced immunogenic cell death in syngeneic mouse models of ovarian cancer

  • J Control Release. 2021 Apr 10;332:448-459. doi: 10.1016/j.jconrel.2021.02.032.
Jiao Zheng 1,  Jiangchuan Sun 2,  Jia Chen 3,  Shenyin Zhu 4,  Shuning Chen 2,  Yujiao Liu 2,  Lan Hao 5,  Zhigang Wang 5,  Shufang Chang 6
Affiliations

Affiliations

  • 1 Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China; Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • 2 Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • 3 Department of Obstetrics and Gynecology, Chongqing University Central Hospital (Chongqing Emergency Medical Center), Chongqing 400014, China.
  • 4 Department of Pharmacy, the First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
  • 5 Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China.
  • 6 Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China. Electronic address: shfch2018@hospital.cqmu.edu.cn.
PMID: 33662456 DOI: 10.1016/j.jconrel.2021.02.032
Abstract

Immunotherapy by stimulating the host immune system has been a promising therapeutic strategy for advanced ovarian Cancer. Here we describe a treatment strategy that combines chemotherapy and photo-sonodynamic therapy (PSDT) to induce systemic antitumor immunity. We have successfully fabricated phase-changeable core-shell nanoparticles (OIX_NPs), which carry oxygen in the core and the photosensitizer indocyanine green (ICG)/oxaliplatin (OXP) in the shell for our combination therapy. In the present study, we demonstrated that OIX_NPs have great potential as contrast agents to enhance photoacoustic (PA) imaging. Furthermore, our combined strategy could induce immunogenic cell death (ICD) by promoting surface exposure of calreticulin (CRT) and passive release of high-mobility group box 1 (HMGB1). Importantly, it could inhibit the growth not only primary tumors but also distant tumors in a bilateral syngeneic mouse model by increasing intratumor infiltration of cytotoxic T lymphocytes. In conclusion, the combination of chemotherapy and PSDT has the potential to enhance antitumor immunity significantly and achieve the integration of diagnosis and treatment for ovarian Cancer.

Keywords

Abscopal effect; Chemotherapy; Immunogenic cell death; Multifunctional nanoparticles; Photo-sonodynamic therapy.

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