2. Academic Validation
  3. 3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp

3-Hydroxy-4-methyldecanoic Acid-Containing Cyclotetradepsipeptides from an Endolichenic Beauveria sp

  • J Nat Prod. 2021 Apr 23;84(4):1244-1253. doi: 10.1021/acs.jnatprod.0c01305.
Yuan-Fei Zhou 1 2,  Kun Hu 1,  Fang Wang 1,  Jian-Wei Tang 1,  Liang Zhang 1,  Han-Dong Sun 1,  Xiang-Hai Cai 1,  Pema-Tenzin Puno 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201 Yunnan, People's Republic of China.
  • 2 University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
PMID: 33754723 DOI: 10.1021/acs.jnatprod.0c01305
Abstract

An investigation of an endolichenic Beauveria sp. led to the discovery of seven new cyclotetradepsipeptides, beauveamides A-G (2-8), along with the known beauverolide Ka (1). All incorporate a 3-hydroxy-4-methyldecanoic acid (HMDA) moiety in their structures. Their configuration was determined through Marfey's, J-based configuration analysis, and NMR computational methods, representing the first time that the stereostructures of HMDA-moiety-containing cyclotetradepsipeptides have been established. Compounds 1 and 2 exhibited protecting effects on HEI-OC1 cells at 10 μM, while 1, 4, and 5 could stimulate glucose uptake in cultured rat L6 myoblasts at 50 μM. Compound 1 showed dose-dependent activity in both L6 myoblasts and myotubes.

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