Synthesis and anti-tumor activity of marine alkaloids

Bioorg Med Chem Lett. 2021 Jun 1:41:128009. doi: 10.1016/j.bmcl.2021.128009.

Shiyang Zhou ¹, Gangliang Huang ², Guangying Chen ³

Affiliations

1 College of Chemistry, Chongqing Normal University, Chongqing 401331, China; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.
2 College of Chemistry, Chongqing Normal University, Chongqing 401331, China. Electronic address: huangdoctor226@163.com.
3 Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou, Hainan 571158, China.

PMID: 33831559 DOI: 10.1016/j.bmcl.2021.128009

Abstract

Marine Alkaloids were divided into five categories from the perspective of anti-tumor activity. The optimization process, chemical synthesis, anti-tumor activity evaluation and structure-activity relationship of various compounds were discussed.

Keywords

Anti-tumor activity; Marine alkaloid; Synthesis.

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