2. Academic Validation
  3. Biguanides: Species with versatile therapeutic applications

Biguanides: Species with versatile therapeutic applications

  • Eur J Med Chem. 2021 Jul 5:219:113378. doi: 10.1016/j.ejmech.2021.113378.
Deepika Kathuria 1,  Akshay D Raul 2,  Pravin Wanjari 2,  Prasad V Bharatam 3
Affiliations

Affiliations

  • 1 University Center for Research and Development, Chandigarh University, Gharuan, Punjab, 140413, India.
  • 2 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, 160 062, Punjab, India.
  • 3 Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, S. A. S. Nagar, 160 062, Punjab, India. Electronic address: pvbharatam@niper.ac.in.
PMID: 33857729 DOI: 10.1016/j.ejmech.2021.113378
Abstract

Biguanides are compounds in which two guanidine moieties are fused to form a highly conjugated system. Biguanides are highly basic and hence they are available as salts mostly hydrochloride salts, these cationic species have been found to exhibit many therapeutic properties. This review covers the research and development carried out on biguanides and accounts the various therapeutic applications of drugs containing biguanide group-such as antimalarial, antidiabetic, Antiviral, Anticancer, Antibacterial, Antifungal, anti-tubercular, antifilarial, anti-HIV, as well as Other biological activities. The aim of this review is to compile all the medicinal chemistry applications of this class of compounds so as to pave way for the accelerated efforts in finding the drug action mechanisms associated with this class of compounds. Importance has been given to the organic chemistry of these biguanide derivatives also.

Keywords

Anticancer activity; Antimalarial activity; Antiviral activity; Biguanide; Metformin.

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