2. Academic Validation
  3. Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

Structurally Diverse Sesquiterpenoids with Anti-neuroinflammatory Activity from the Endolichenic Fungus Cryptomarasmius aucubae

  • Nat Prod Bioprospect. 2021 Jun;11(3):325-332. doi: 10.1007/s13659-021-00299-9.
Yi-Jie Zhai 1,  Jian-Nan Li 1,  Yu-Qi Gao 1,  Lin-Lin Gao 1,  Da-Cheng Wang 1,  Wen-Bo Han 2,  Jin-Ming Gao 3
Affiliations

Affiliations

  • 1 Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China.
  • 2 Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. wbhan@nwafu.edu.cn.
  • 3 Shaanxi Key Laboratory of Natural Products and Chemical Biology, College of Chemistry and Pharmacy, Northwest A&F University, Yangling, Shaanxi, 712100, People's Republic of China. jinminggao@nwsuaf.edu.cn.
PMID: 33963522 DOI: 10.1007/s13659-021-00299-9
Abstract

Two new sterpurane sesquiterpenoids named sterpurol D (1) and sterpurol E (2), and one skeletally new sesquiterpene, cryptomaraone (3), bearing a 5,6-fused bicyclic ring system, along with five known ones, sterpurol A (4), sterpurol B (5), paneolilludinic Acid (6), murolane-2α, 9β-diol-3-ene (7) and (-)-10,11-dihydroxyfarnesol (8) were isolated from an endolichenic fungus Cryptomarasmius aucubae. The structures of the new compounds were elucidated by analysis of NMR spectroscopic spectra and HRESIMS data. The absolute configurations of 1 and 2 were established by spectroscopic data analysis and comparison of specific optical rotation, as well as the biosynthetic consideration. Additionally, compounds 1, 2, 4-6, and 8 showed significant nitric oxide (NO) production inhibition in Lipopolysaccharide (LPS)-induced BV-2 microglial cells with the IC50 values ranging from 9.06 to 14.81 μM.

Keywords

Anti-neuroinflammatory activity; Cryptomarasmius aucubae; Endolichenic fungus; Sesquiterpenes.

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