1. Academic Validation
  2. Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

Chrysin Improves Glucose and Lipid Metabolism Disorders by Regulating the AMPK/PI3K/AKT Signaling Pathway in Insulin-Resistant HepG2 Cells and HFD/STZ-Induced C57BL/6J Mice

  • J Agric Food Chem. 2021 May 26;69(20):5618-5627. doi: 10.1021/acs.jafc.1c01109.
Ying-Jun Zhou 1 Nuo Xu 1 Xiao-Chen Zhang 1 Yu-Yan Zhu 1 Shao-Wei Liu 1 Ya-Ning Chang 1
Affiliations

Affiliation

  • 1 The State Key Laboratory of Bioreactor Engineering, College of Bioengineering, East China University of Science and Technology, No.130 Meilong Road, Xuhui District, Shanghai 200237, People's Republic of China.
Abstract

Natural Products with minor side effects have been reported to be an effective Adjuvant therapy for glucose and lipid metabolism disorders. Chrysin, a flavone, has a wide range of physiological effects, such as antioxidant, anti-inflammatory, anti-diabetes, anti-hyperlipidemia, and hepatoprotective. This study was designed to explore the effects and mechanism of chrysin on metabolic syndrome using insulin-resistant HepG2 cells and HFD/STZ-induced C57BL/6J mice. The results indicated that chrysin significantly decreased Insulin resistance, oxidative stress, inflammation, and liver injury. In addition, chrysin improved glycogen synthesis and fatty acid oxidation and inhibited gluconeogenesis and fatty acid synthesis by regulating GSK3β, G6Paes, PEPCK, SREBP1, FAS, and ACC1. Furthermore, the results of western blot and Real-Time PCR experiments demonstrated that chrysin modulated glucose and lipid metabolism through the AMPK/PI3K/Akt signaling pathway. Treatment with the AMPK Inhibitor verified that AMPK activation is positively correlated with chrysin activity on glycolipid metabolism. This study confirms that chrysin is a potential treatment for glucose and lipid metabolism disorders.

Keywords

AKT; AMPK; chrysin; glucose metabolism; lipid metabolism.

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