2. Academic Validation
  3. ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer

  • Nat Cancer. 2021 May;2(5):503-514. doi: 10.1038/s43018-021-00208-6.
Jiehui Deng 1,  Aatish Thennavan 2,  Igor Dolgalev 3,  Ting Chen 1,  Jie Li 3 4,  Antonio Marzio 3 4,  John T Poirier 5,  David H Peng 1,  Mirna Bulatovic 1,  Subhadip Mukhopadhyay 6,  Heather Silver 1,  Eleni Papadopoulos 1,  Val Pyon 1,  Cassandra Thakurdin 1,  Han Han 1,  Fei Li 1,  Shuai Li 1,  Hailin Ding 1,  Hai Hu 1,  Yuanwang Pan 1,  Vajira Weerasekara 7 8,  Baishan Jiang 9 10,  Eric S Wang 9 10,  Ian Ahearn 11,  Mark Philips 11,  Thales Papagiannakopoulos 3 12,  Aristotelis Tsirigos 3,  Eli Rothenberg 4,  Justin Gainor 7,  Gordon J Freeman 13,  Charles M Rudin 14,  Nathanael S Gray 15,  Peter S Hammerman 13,  Michele Pagano 3 4 16,  John V Heymach 17,  Charles M Perou 2,  Nabeel Bardeesy 7 8,  Kwok-Kin Wong 18
Affiliations

Affiliations

  • 1 Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA.
  • 2 Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA.
  • 3 Laura and Isaac Perlmutter Cancer Center, NYU Langone Medical Center, New York University, New York, NY, USA.
  • 4 Department of Biochemistry and Molecular Pharmacology, New York University School of Medicine, New York, NY, USA.
  • 5 Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • 6 Department of Radiation Oncology, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
  • 7 Center for Cancer Research, Massachusetts General Hospital, Boston, MA, USA.
  • 8 Department of Medicine, Harvard Medical School, Boston, MA, USA.
  • 9 Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • 10 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
  • 11 Department of Medicine, Laura and Isaac Perlmutter Cancer Center, New York University School of Medicine, New York, NY, USA.
  • 12 Department of Pathology, New York University School of Medicine, New York, NY, USA.
  • 13 Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • 14 Memorial Sloan Kettering Cancer Center, New York, NY, USA.
  • 15 Department of Chemical and Systems Biology, Chem-H and Stanford Cancer Institute, Stanford School of Medicine, Stanford University, Stanford, CA, USA.
  • 16 Howard Hughes Medical Institute, New York University School of Medicine, New York, NY, USA.
  • 17 Departments of Thoracic/Head and Neck Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
  • 18 Division of Hematology & Medical Oncology, Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, NY, USA. Kwok-Kin.Wong@nyulangone.org.
PMID: 34142094 DOI: 10.1038/s43018-021-00208-6
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