2. Academic Validation
  3. Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

Pluronic F127 micelles improve the stability and enhance the anticancer stem cell efficacy of citral in breast cancer

  • Nanomedicine (Lond). 2021 Jul;16(17):1471-1485. doi: 10.2217/nnm-2021-0013.
Marwa M Abu-Serie 1,  Fernanda Andrade 2 3,  Patricia Cámara-Sánchez 2 3 4,  Joaquin Seras-Franzoso 2 3,  Diana Rafael 2 3,  Zamira V Díaz-Riascos 2 3 4,  Petra Gener 2 3,  Ibane Abasolo 2 3 4,  Simó Schwartz Jr 2 3
Affiliations

Affiliations

  • 1 Department of Medical Biotechnology, Genetic Engineering, & Biotechnology Research Institute, City of Scientific Research & Technological Applications (SRTA-City), New Borg EL-Arab, 21934, Alexandria, Egypt.
  • 2 Drug Delivery & Targeting, CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035, Barcelona, Spain.
  • 3 Networking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), 08035, Barcelona, Spain.
  • 4 Functional Validation & Preclinical Research (FVPR), CIBBIM-Nanomedicine, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona (UAB), 08035, Barcelona, Spain.
PMID: 34160295 DOI: 10.2217/nnm-2021-0013
Abstract

Aim: Improving the stability and anti-cancer stem cell (CSC) activity of citral, a natural ALDH1A inhibitor. Materials & methods: Citral-loaded micelles (CLM) were obtained using Pluronic® F127 and its efficacy tested on the growth of four breast Cancer cell lines. The impact of the CLM on the growth and functional hallmarks of breast CSCs were also evaluated using mammosphere and CSC reporter cell lines. Results: CLM improved the stability and growth inhibitory effects of citral. Importantly, CLM fully blocking the stemness features of CSCs (self-renewal, differentiation and migration) and in combination with paclitaxel CLM sensitized breast Cancer cells to the chemotherapy. Conclusion: Targeting CSCs with CLM could improve the treatment of advanced breast Cancer in combination with the standard chemotherapy.

Keywords

F127; Pluronic®; breast cancer; cancer stem cells; citral; polymeric micelles.

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