2. Academic Validation
  3. MCP-1: Function, regulation, and involvement in disease

MCP-1: Function, regulation, and involvement in disease

  • Int Immunopharmacol. 2021 Dec;101(Pt B):107598. doi: 10.1016/j.intimp.2021.107598.
Sanjiv Singh 1,  D Anshita 2,  V Ravichandiran 2
Affiliations

Affiliations

  • 1 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India. Electronic address: sanjivpg2006@yahoo.com.
  • 2 Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Export Promotion Industrial Park (EPIP), Zandaha Road, Hajipur, Bihar, India.
PMID: 34233864 DOI: 10.1016/j.intimp.2021.107598
Abstract

MCP-1 (Monocyte chemoattractant protein-1), also known as Chemokine (CC-motif) ligand 2 (CCL2), is from family of CC Chemokines. It has a vital role in the process of inflammation, where it attracts or enhances the expression of Other inflammatory factors/cells. It leads to the advancement of many disorders by this main mechanism of migration and infiltration of inflammatory cells like monocytes/macrophages and Other cytokines at the site of inflammation. MCP-1 has been inculpated in the pathogenesis of numerous disease conditions either directly or indirectly like novel corona virus, cancers, neuroinflammatory diseases, rheumatoid arthritis, cardiovascular diseases. The elevated MCP-1 level has been observed in COVID-19 patients and proven to be a biomarker associated with the extremity of disease along with IP-10. This review will focus on involvement and role of MCP-1 in various pathological conditions.

Keywords

CCL2; COVID-19; Cancer; Endothelial dysfunction; Monocyte chemoattractant protein-1; NF-ĸB; Oxidative stress.

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