2. Academic Validation
  3. Epetraborole Is Active against Mycobacterium abscessus

Epetraborole Is Active against Mycobacterium abscessus

  • Antimicrob Agents Chemother. 2021 Sep 17;65(10):e0115621. doi: 10.1128/AAC.01156-21.
Uday S Ganapathy 1,  Martin Gengenbacher 1 2,  Thomas Dick 1 2 3
Affiliations

Affiliations

  • 1 Center for Discovery and Innovation, Hackensack Meridian Health, Nutley, New Jersey, USA.
  • 2 Department of Medical Sciences, Hackensack Meridian School of Medicine, Nutley, New Jersey, USA.
  • 3 Department of Microbiology and Immunology, Georgetown University, Washington, DC, USA.
PMID: 34280020 DOI: 10.1128/AAC.01156-21
Abstract

Benzoxaboroles are a new class of leucyl-tRNA synthetase inhibitors. We recently reported that the antitubercular 4-halogenated benzoxaboroles are active against Mycobacterium abscessus. Here, we find that the nonhalogenated benzoxaborole epetraborole, a clinical candidate developed for Gram-negative infections, is also active against M. abscessus in vitro and in a mouse model of Infection. This expands the repertoire of advanced lead compounds for the discovery of a benzoxaborole-based candidate to treat M. abscessus lung disease.

Keywords

Mycobacterium abscessus; NTM; benzoxaborole; epetraborole; nontuberculous mycobacteria.

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