2. Academic Validation
  3. CXCL11 Signaling in the Tumor Microenvironment

CXCL11 Signaling in the Tumor Microenvironment

  • Adv Exp Med Biol. 2021;1302:41-50. doi: 10.1007/978-3-030-62658-7_4.
Qun Gao 1,  Yi Zhang 2
Affiliations

Affiliations

  • 1 Biotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
  • 2 Biotherapy Center and Cancer Center, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, People's Republic of China. yizhang@zzu.edu.cn.
PMID: 34286440 DOI: 10.1007/978-3-030-62658-7_4
Abstract

CXCL11 which can bind to two different chemokine receptors, CXCR3 and CXCR7, has found a prominent place in current tumor research. In this chapter, we mainly discuss the current evidence on the role of the immune response of CXCL11 in tumor microenvironment (TME). The diverse functions of CXCL11 include inhibiting angiogenesis, affecting the proliferation of different cell types, playing a role in fibroblast directed carcinoma invasion, increasing adhesion properties, suppressing M2 macrophage polarization, and facilitating the migration of certain immune cells. In addition, we discussed the application of CXCL11 as an Adjuvant to various mainstream anti-cancer therapies and the future challenges in the application of CXCL11 targeted therapies.

Keywords

Angiogenesis; CXCL11; CXCR3; CXCR7; Cell adhesion; Cytotoxic T lymphocytes; Fibroblast migration; Immune cells; Immune cells migration; Polarization of immune cells; Proliferation; Self-renewal; Tumor microenvironment; Tumorigenicity; vvDD-CXCL11.

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