2. Academic Validation
  3. Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L

Neo-clerodane Diterpenoids with Hypoglycemic Effects in Vivo from the Aerial Parts of Salvia hispanica L

  • Chem Biodivers. 2021 Sep;18(9):e2100517. doi: 10.1002/cbdv.202100517.
Min Fan 1 2,  Ting Wang 3,  Li-Yan Peng 1,  Jun-Shang Huang 3,  Xing-De Wu 1,  He-Yao Wang 3,  Qin-Shi Zhao 1
Affiliations

Affiliations

  • 1 State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, P. R. China.
  • 2 College of Pharmacy, Dali University, Dali, 671000, P. R. China.
  • 3 Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, P. R. China.
PMID: 34292661 DOI: 10.1002/cbdv.202100517
Abstract

A new neo-clerodane diterpenoid, salvihispin H (1), and six known ones (2-7) were identified from the aerial parts of Salvia hispanica L. The structure and absolute configuration of 1 were elucidated by extensive analysis of spectroscopic (1 H, 13 C, and 2D NMR, and HR-ESI-MS) and single-crystal X-ray diffraction data. The anti-diabetic effects of salvihispin H (1) and salvifaricin (2) were evaluated in diabetic db/db mice. The data showed that 1 and 2 could significantly reduce fasting blood glucose level and improve Insulin resistance, and compound 1 exerted glucose-lowering effect more quickly than metformin. In addition, 1 and 2 could also reduce serum TG level in db/db mice. These results demonstrated that compounds 1 and 2 could be considered as potent candidates for the therapy of type 2 diabetes mellitus (T2DM).

Keywords

Salvia hispanica; neo-clerodane diterpenoid; salvihispin H; type 2 diabetes mellitus.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-N3458A
    Clerodane Diterpenoid