2. Academic Validation
  3. Adduct of Aquacobalamin with Hydrogen Peroxide

Adduct of Aquacobalamin with Hydrogen Peroxide

  • Inorg Chem. 2021 Sep 6;60(17):12681-12684. doi: 10.1021/acs.inorgchem.1c01483.
Maria Lehene 1,  Diana Plesa 1,  Stefania Ionescu-Zinca 1,  Stefania D Iancu 2,  Nicolae Leopold 2,  Sergei V Makarov 3,  Adrian M V Brânzanic 1,  Radu Silaghi-Dumitrescu 1
Affiliations

Affiliations

  • 1 Department of Chemistry, Babes-Bolyai University (BBU), Str. Arany Janos Nr. 11, RO-400028 Cluj-Napoca, Romania.
  • 2 Faculty of Physics, Babes-Bolyai University (BBU), Str. Kogalniceanu 1, RO-400084 Cluj-Napoca, Romania.
  • 3 Ivanovo State University of Chemistry and Technology, Sheremetevskiy Str. 7, 153000 Ivanovo, Russia.
PMID: 34382784 DOI: 10.1021/acs.inorgchem.1c01483
Abstract

Aquacobalamin binds hydrogen peroxide reversibly to form a cobalt(III) hydroperoxo adduct with a 0.25 mM dissociation constant, as evidenced by UV-vis absorption spectroscopy and corroborated by NMR, Raman spectroscopy, stopped-flow UV-vis measurements, and density functional theory calculations.

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