2. Academic Validation
  3. Role of hemoglobin structural-functional relationships in oxygen transport

Role of hemoglobin structural-functional relationships in oxygen transport

  • Mol Aspects Med. 2022 Apr;84:101022. doi: 10.1016/j.mam.2021.101022.
Chiara Ciaccio 1,  Andrea Coletta 2,  Massimo Coletta 3
Affiliations

Affiliations

  • 1 Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy.
  • 2 WasteHero, Aarhus, Denmark.
  • 3 Department of Clinical Sciences and Translational Medicine, University of Roma Tor Vergata, Via Montpellier 1, I-00133 Roma, Italy; IRCCS Fondazione Bietti, Rome, Italy. Electronic address: coletta@med.uniroma2.it.
PMID: 34509280 DOI: 10.1016/j.mam.2021.101022
Abstract

The molecular mechanism of O2 binding to hemoglobin (Hb) has been critically reviewed on the basis of the information built up in the last decades. It allows to describe in detail from the kinetic and thermodynamic viewpoint the process of O2 uptake in the lungs and release to the tissues, casting some LIGHT on the physiological and pathological aspects of this process. The relevance of structural-functional relationships for O2 binding is particularly outlined in the case of poorly vascularized tissues, such as retina, briefly discussing of strategies employed for optimization of oxygen supply to this type of tissues.

Keywords

Cooperativity; Hemoglobin; Mechanism models; Oxygen delivery to retina; Oxygen transport.

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