2. Academic Validation
  3. Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy

Biomimetic Platform Based on Mesoporous Platinum for Multisynergistic Cancer Therapy

  • ACS Biomater Sci Eng. 2021 Nov 8;7(11):5154-5164. doi: 10.1021/acsbiomaterials.1c00912.
Gaoqian Zhao 1 2,  Jiaxin Li 1 2,  Fangfang Lv 1 2,  Xiaochun Wang 3,  Qing Dong 1 2,  Dandan Liu 2 4,  Jinchao Zhang 2 4,  Zhenhua Li 5,  Xiaohan Zhou 5,  Huifang Liu 1 2
Affiliations

Affiliations

  • 1 College of Pharmaceutical Science, Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China.
  • 2 Key Laboratory of Medicinal Chemistry and Molecular Diagnosis of Ministry of Education, Chemical Biology Key Laboratory of Hebei Province, Institute of Life Science and Green Development, Hebei University, Baoding 071002, China.
  • 3 Affiliated Hospital of Hebei University, Baoding 071000, China.
  • 4 College of Chemistry & Environmental Science, Hebei University, Baoding 071002, China.
  • 5 Dongguan Institute of Clinical Cancer Research, Affiliated Dongguan Hospital, Southern Medical University, Dongguan 523059, China.
PMID: 34636537 DOI: 10.1021/acsbiomaterials.1c00912
Abstract

Photothermal therapy (PTT) using nanoparticles is one of the research hotspots in the field of Cancer therapy. However, the thermal resistance of tumor cells and the elimination of nanoparticles by the body's immune system reduce their therapeutic effect. Therefore, it is essential to reduce heat resistance, improve their biocompatibility, and reduce the clearance of the immune system. In this work, we constructed a biomimetic platform for Cancer therapy based on heat shock protein (HSP) inhibitors, 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG))-loaded and platelet membrane (PM)-coated mesoporous platinum nanoparticles (MPNPs). First, MPNPs with the properties of chemotherapy and PTT were synthesized to load 17-DMAG (17-DMAG/MPNPs). Then, they were coated with PM for tumor targeting and improved biocompatibility to obtain the final bionic nanotherapy platform 17-DMAG/MPNPs@PM. The results in vivo and in vitro showed that 17-DMAG/MPNPs@PM could accumulate in the tumor and effectively inhibit the growth of tumor cells. Therefore, the biomimetic nanotherapy system is expected to provide new ideas for Cancer treatment.

Keywords

biomimetic platform; heat shock protein 90; mesoporous platinum; photothermal therapy; platelet membrane.

Figures
Products
  • Cat. No.
    Product Name
    Description
    Target
    Research Area
  • HY-10389
    99.59%, Hsp90 Inhibitor
    HSP