2. Academic Validation
  3. Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy

Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy

  • Proc Natl Acad Sci U S A. 1986 Nov;83(22):8435-9. doi: 10.1073/pnas.83.22.8435.
R S Moog,  M A McGuirl,  C E Cote,  D M Dooley
PMID: 3464962 DOI: 10.1073/pnas.83.22.8435
Abstract

Resonance Raman spectra of the 2,4-dinitrophenylhydrazine derivatives of bovine plasma amine oxidase [amine:oxygen oxidoreductase (deaminating) (copper-containing), EC 1.4.3.6] have been measured. Detailed comparisons to the spectra of the corresponding derivatives of methoxatin (pyrroloquinolinequinone), pyridoxal, and other aldehydes and diones provide further evidence that covalently bound methoxatin or a closely similar derivative is the organic cofactor in copper-containing amine oxidases.

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