2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. Pyrroloquinoline quinone

Pyrroloquinoline quinone  (Synonyms: PQQ; Methoxatin)

Cat. No.: HY-100196 Purity: 99.58%
SDS COA Handling Instructions

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Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function.

For research use only. We do not sell to patients.

Pyrroloquinoline quinone Chemical Structure

Pyrroloquinoline quinone Chemical Structure

CAS No. : 72909-34-3

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Based on 3 publication(s) in Google Scholar

Other Forms of Pyrroloquinoline quinone:

Pyrroloquinoline quinone Related Antibodies

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Description

Pyrroloquinoline quinone (PQQ), a redox co-factor, is an anionic, redox-cycling orthoquinone. Pyrroloquinoline quinone is isolated from cultures of methylotropic bacteria and tissues of mammals. Pyrroloquinoline quinone is an essential nutrient for mammals and is important for immune function[1][2].

IC50 & Target[1]

Microbial Metabolite

 

Human Endogenous Metabolite

 

Cellular Effect
Cell Line Type Value Description References
A549 IC50
750.1 μM
Compound: PQQ
Antiproliferative against human A549 cells after 48 hrs by MTT assay
Antiproliferative against human A549 cells after 48 hrs by MTT assay
[PMID: 24996136]
HepG2 IC50
45.71 μM
Compound: PQQ
Antiproliferative against human HepG2 cells after 48 hrs by MTT assay
Antiproliferative against human HepG2 cells after 48 hrs by MTT assay
[PMID: 24996136]
MCF7 IC50
25.48 μM
Compound: PQQ
Antiproliferative against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative against human MCF7 cells after 48 hrs by MTT assay
[PMID: 24996136]
In Vitro

Mouse pups born to and nursing from Pyrroloquinoline quinone (PQQ)-deprived dams have a compromised immune response as well as alopecia, a hunched posture, and a susceptibility to aortic aneurysms[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pyrroloquinoline quinone Related Antibodies
Molecular Weight

330.21

Formula

C14H6N2O8
CAS No.
Appearance

Solid

Color

Pink to red

SMILES

O=C(C(N1)=CC(C2=O)=C1C3=C(N=C(C(O)=O)C=C3C(O)=O)C2=O)O
Structure Classification
Initial Source

cultures of methylotropic bacteria and tissues of mammals
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 1 mg/mL (3.03 mM; ultrasonic and warming and heat to 60°C)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0284 mL 15.1419 mL 30.2838 mL
5 mM --- --- ---
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 1 mg/mL (3.03 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

  • Protocol 2

    Add each solvent one by one:  0.5% CMC/saline water

    Solubility: 4 mg/mL (12.11 mM); Suspended solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.58%

SDS (393 KB)

COA (255 KB) HNMR (237 KB) RP-HPLC (259 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.0284 mL 15.1419 mL 30.2838 mL 75.7094 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Pyrroloquinoline quinone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pyrroloquinoline quinone72909-34-3PQQ MethoxatinEndogenous Metaboliteredoxco-factoranionicmethylotropicbacteriaessentialnutrientimmunefunctionInhibitorinhibitorinhibit

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