2. Academic Validation
  3. Macrocyclic Diterpenoid Constituents of Euphorbia deflexa, an Endemic Spurge from Greece

Macrocyclic Diterpenoid Constituents of Euphorbia deflexa, an Endemic Spurge from Greece

  • J Nat Prod. 2021 Nov 26;84(11):2893-2903. doi: 10.1021/acs.jnatprod.1c00654.
Maria-Eleni Grafakou 1 2,  Christina Barda 1,  Joerg Heilmann 2,  Helen Skaltsa 1
Affiliations

Affiliations

  • 1 Department of Pharmacognosy & Chemistry of Natural Products, Faculty of Pharmacy, School of Health Sciences, National & Kapodistrian University of Athens, Athens 157 72, Greece.
  • 2 Department of Pharmaceutical Biology, Faculty of Chemistry and Pharmacy, University of Regensburg, 93053 Regensburg, Germany.
PMID: 34665635 DOI: 10.1021/acs.jnatprod.1c00654
Abstract

Euphorbia deflexa, an endemic spurge from Greece, was investigated for the occurrence of its diterpene constituents. Through continuous monitoring by 1H NMR, 22 Diterpenoids were isolated, including 16 previously undescribed compounds (euphodeflexins A-P), which belong to the jatrophane, ingenane, segetane, and pepluane diterpene types. Their chemical structures were elucidated through a combination of HRESIMS, NMR spectroscopy, and X-ray data. The isolated Diterpenoids were tested against a panel of human Cancer cell lines, as well as against two Bacterial strains. Compounds 1, 13, and 17 were active against the HeLa cell line with IC50 values 9.9, 9.8, and 5.8 μM, respectively.

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