2. Academic Validation
  3. L-Lysine α-Oxidase: Enzyme with Anticancer Properties

L-Lysine α-Oxidase: Enzyme with Anticancer Properties

  • Pharmaceuticals (Basel). 2021 Oct 22;14(11):1070. doi: 10.3390/ph14111070.
Elena V Lukasheva 1,  Gulalek Babayeva 1 2,  Saida Sh Karshieva 2,  Dmitry D Zhdanov 3,  Vadim S Pokrovsky 1 2 4
Affiliations

Affiliations

  • 1 Department of Biochemistry, Peoples' Friendship University of Russia (RUDN University), Miklukho-Maklaya Street 6, 117198 Moscow, Russia.
  • 2 Laboratory of Combined Treatment, N.N. Blokhin Cancer Research Center, Kashirskoe Shosse 24, 115478 Moscow, Russia.
  • 3 Institute of Biomedical Chemistry, Pogodinskaya Street 10/8, 119121 Moscow, Russia.
  • 4 Center of Genetics and Life Sciences, Sirius University of Science and Technology, Federal Territory Sirius, 1 Olimpiisky Prospect, 354340 Sochi, Russia.
PMID: 34832852 DOI: 10.3390/ph14111070
Abstract

L-lysine α-oxidase (LO), one of L-amino acid oxidases, deaminates L-lysine with the yield of H2O2, ammonia, and α-keto-ε-aminocaproate. Multiple in vitro and in vivo studies have reported cytotoxic, antitumor, antimetastatic, and antitumor activity of LO. Unlike asparaginase, LO has a dual mechanism of action: depletion of L-lysine and formation of H2O2, both targeting tumor growth. Prominent results were obtained on murine and human tumor models, including human colon Cancer xenografts HCT 116, LS174T, and T47D with maximum T/C 12, 37, and 36%, respectively. The data obtained from human Cancer xenografts in immunodeficient mice confirm the potential of LO as an agent for colon Cancer treatment. In this review, we discuss recently discovered molecular mechanisms of biological action and the potential of LO as Anticancer enzyme.

Keywords

L-amino acid oxidase; L-lysine; L-lysine α-oxidase; anticancer enzymes; colon cancer treatment; tumor therapy.

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