2. Academic Validation
  3. Healing Diabetic Ulcers with MoO3-X Nanodots Possessing Intrinsic ROS-Scavenging and Bacteria-Killing Capacities

Healing Diabetic Ulcers with MoO3-X Nanodots Possessing Intrinsic ROS-Scavenging and Bacteria-Killing Capacities

  • Small. 2022 Mar;18(10):e2107137. doi: 10.1002/smll.202107137.
Guangxin Duan 1,  Ling Wen 2 3,  Xingwei Sun 4,  Zhuxin Wei 5,  Ruixue Duan 1,  Jiangfeng Zeng 1,  Jiabin Cui 1,  Chunyi Liu 1,  Zepeng Yu 4,  Xiaofang Xie 6,  Mingyuan Gao 1 7
Affiliations

Affiliations

  • 1 Center for Molecular Imaging and Nuclear Medicine, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Collaborative Innovation Center of Radiological Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, China.
  • 2 Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou, 215000, China.
  • 3 Institute of Medical Imaging, Soochow University, Suzhou, 215000, China.
  • 4 Department of Intervention, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
  • 5 Department of Radiology, The Dushu Lake Hospital Affiliated to Soochow University, Suzhou, 215123, China.
  • 6 Department of Clinical Laboratory, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
  • 7 Clinical Translation Center of State Key Lab, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.
PMID: 34927361 DOI: 10.1002/smll.202107137
Abstract

Diabetic ulcers (DUs) appearing as chronic wounds are difficult to heal due to the oxidative stress in the wound microenvironment and their high susceptibility to Bacterial infection. A routine treatment combining surgical debridement with Anti-infection therapy is widely used for treating DUs in the clinic, but hardly offers a satisfying wound healing outcome. It is known that a long-term Antibiotic treatment may also lead to the drug resistance of pathogens. To address these challenges, new strategies combining both Reactive Oxygen Species (ROS) scavenging and Bacterial sterilization have been proposed for fighting against DUs. Following this idea, oxygen deficient molybdenum-based nanodots (MoO3-X ) for healing the DUs are reported. The ROS scavenging ability of MoO3-X nanodots is investigated and the Antibacterial property of the nanodots is also demonstrated. The systematic cell and animal experimental results indicate that the MoO3-X nanodots can effectively reduce inflammation, promote epithelial cell regeneration, accelerate angiogenesis, and facilitate DUs recovery. Most importantly, they present excellent capacity to diminish Infection of methicillin-resistant Staphylococcus aureus, manifesting the potent application prospect of MoO3-X nanodots for diabetic wound therapy.

Keywords

MoO 3− X nanodots; ROS scavenging; antibacterial activity; diabetic ulcers; wound healing.

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