2. Academic Validation
  3. Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

Hypoglycemic flavonoids from Selaginella tamariscina (P.Beauv.) Spring

  • Phytochemistry. 2022 Mar;195:113073. doi: 10.1016/j.phytochem.2021.113073.
Hong-Ping Long 1,  Jian Liu 2,  Ping-Sheng Xu 3,  Kang-Ping Xu 4,  Jing Li 5,  Gui-Shan Tan 6
Affiliations

Affiliations

  • 1 The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, PR China; Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China.
  • 2 The First Hospital of Hunan University of Chinese Medicine, Changsha, 410007, PR China.
  • 3 Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, 410008, PR China.
  • 4 Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China.
  • 5 Department of Pharmacy, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China. Electronic address: lijingliyun@csu.edu.cn.
  • 6 Phase I Clinical Trial Center, Xiangya Hospital, Central South University, Changsha, 410008, PR China; Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, 410013, PR China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, PR China. Electronic address: tgs395@csu.edu.cn.
PMID: 34974412 DOI: 10.1016/j.phytochem.2021.113073
Abstract

Six Flavonoids, namely, three undescribed biflavonoids, one undescribed 8-aryl flavonoid, and two known compounds, were isolated from Selaginella tamariscina (P.Beauv.) Spring. The structures and absolute configurations of those undescribed compounds were established by NMR spectroscopy data, HRESIMS analyses and electronic circular dichroism (ECD) analyses. In addition, all the isolates were evaluated for their hypoglycemic activity in HepG2 cells. Involvenflavone H, I, and J significantly increased glucose consumption in both normal and insulin-resistant HepG2 cells. Interestingly, these three compounds can effectively upregulate the protein expression of Glucokinase (GCK) and adenylate cyclases (ADCYs). These results suggested that involvenflavone H, I, and J (especially involvenflavone J) may have potent hypoglycemic activity, which also provided promising molecular targets for the treatment of diabetes.

Keywords

Flavonoids; Glucokinase; Hypoglycemic activity; Selaginella tamariscina; Selaginellaceae.

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