2. Academic Validation
  3. The crucial role of prolactin-lactogenic hormone in Covid-19

The crucial role of prolactin-lactogenic hormone in Covid-19

  • Mol Cell Biochem. 2022 May;477(5):1381-1392. doi: 10.1007/s11010-022-04381-9.
Hayder M Al-Kuraishy 1,  Ali I Al-Gareeb 1,  Monica Butnariu 2,  Gaber El-Saber Batiha 3
Affiliations

Affiliations

  • 1 College of Medicine, Al-Mustansiriyah University, P.O. Box 14132, Baghdad, Iraq.
  • 2 Chemistry & Biochemistry Discipline, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania" From Timisoara, Calea Aradului 119, 300645, Timis, Romania. monicabutnariu@yahoo.com.
  • 3 Department of Pharmacology and Therapeutics, Faculty of Veterinary Medicine, Damanhour University, Damanhour, AlBeheira, 22511, Egypt. gaberbatiha@gmail.com.
PMID: 35147901 DOI: 10.1007/s11010-022-04381-9
Abstract

Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which caused by positive-sense single-strand RNA virus known as severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2), PRL serum level is increased. PRL in Covid-19 may exacerbate the underlying inflammatory status by induction release of pro-inflammatory cytokines. However, PRL through its anti-inflammatory effects may reduce the hyperinflammatory status in Covid-19. The underlying mechanism of increasing PRL in Covid-19 is poorly understood. Therefore, in this review we try to find the potential anti-inflammatory or pro-inflammatory role of PRL in Covid-19. As well, this review was aimed to discuss the underlying causes and mechanisms for Covid-19-induced hyperprolactinemia.

Keywords

Anti-inflammatory effects; Covid-19; Pro-inflammatory cytokines; Prolactin.

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