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  2. Photolytic Removal of Red Blood Cell Membranes Camouflaged on Nanoparticles for Enhanced Cellular Uptake and Combined Chemo-Photodynamic Inhibition of Cancer Cells

Photolytic Removal of Red Blood Cell Membranes Camouflaged on Nanoparticles for Enhanced Cellular Uptake and Combined Chemo-Photodynamic Inhibition of Cancer Cells

  • Mol Pharm. 2022 Mar 7;19(3):805-818. doi: 10.1021/acs.molpharmaceut.1c00720.
Yanfei Liu 1 Nachuan Wen 1 Ke Li 2 Minquan Li 2 Shengnan Qian 2 Shiran Li 2 Ting Jiang 1 Ting Wang 2 Yuwei Wu 2 Zhenbao Liu 2 3
Affiliations

Affiliations

  • 1 Department of Pharmaceutical Engineering, College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan 410083, P. R. China.
  • 2 Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410013, P. R. China.
  • 3 Molecular Imaging Research Center of Central South University, Changsha, Hunan 410008, P. R. China.
Abstract

Biomimetic therapeutics offer great potential for Drug Delivery that avoids immune recognition. However, the coated cell membrane usually hinders the cellular uptake of nanoparticles; thus, structure-changeable formulations have attracted increasing attention. Herein, we report photolytic pyropheophorbide a (PA)-inserted red blood cell (RBC) membrane-camouflaged curcumin dimeric prodrug (CUR2-TK)-poly(lactic-co-glycolic acid) (PLGA) nanoparticles [(CUR2-TK)-PLGA@RBC-PA] for enhanced Cancer therapy. In these nanoparticles, the inner core was constructed using PLGA and loaded with our synthesized Reactive Oxygen Species (ROS)-responsive cleavable curcumin dimeric prodrug (CUR2-TK). The nanoparticles generated ROS in response to the LIGHT irradiation attributed to the incorporated PA. The ROS further triggered the lysis of the cell membrane and exposed the nanoparticles for enhanced tumor cellular uptake, and the ROS also cleaved CUR2-TK for controlled CUR drug release. Moreover, the ROS performed photodynamic therapy (PDT). The chemotherapy and PDT produced a combined effect in the treatment of Cancer cells, thus enhancing Anticancer therapeutic efficacy.

Keywords

cancer therapy; curcumin dimeric prodrug; photosensitizer; red blood cell membrane.

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