2. Academic Validation
  3. Cytotoxic Sesquiterpenoids from Ammoides atlantica Aerial Parts

Cytotoxic Sesquiterpenoids from Ammoides atlantica Aerial Parts

  • J Nat Prod. 2022 Mar 25;85(3):647-656. doi: 10.1021/acs.jnatprod.1c01211.
Sihem Boudermine 1 2,  Valentina Parisi 3,  Redouane Lemoui 1,  Tarek Boudiar 4,  Maria Giovanna Chini 5,  Silvia Franceschelli 3,  Michela Pecoraro 3,  Maria Pascale 3,  Giuseppe Bifulco 3,  Alessandra Braca 6 7,  Nunziatina De Tommasi 3,  Marinella De Leo 6 7
Affiliations

Affiliations

  • 1 Département de Chimie, Université de Constantine 1, Constantine, 25000, Algeria.
  • 2 Département de Chimie, Université de 20 Aout 1955, Skikda, 21000, Algeria.
  • 3 Dipartimento di Farmacia, Università degli Studi di Salerno, 84084 Fisciano (SA), Italy.
  • 4 Biotechnology Research Center, Constantine, 25000, Algeria.
  • 5 Dipartimento di Bioscienze e Territorio, 86090 Pesche (IS), Italy.
  • 6 Dipartimento di Farmacia, Università di Pisa, 56126 Pisa, Italy.
  • 7 CISUP, Centro per l'Integrazione della Strumentazione Scientifica, Università di Pisa, 56126 Pisa, Italy.
PMID: 35196017 DOI: 10.1021/acs.jnatprod.1c01211
Abstract

Seven new Terpenoids, namely, guaiane (1-4), eudesmane (5), and bisabolane (6) sesquiterpenoids and a furanone (7), were isolated from the aerial parts of Ammoides atlantica, a herbaceous plant growing in Algeria, together with eight known compounds. All metabolites were characterized by their 1D and 2D NMR and HRESIMS data. A combined DFT/NMR method was applied to study the relative configurations of 1-4, 6, and 7. All compounds, except 2, were assayed against MCF-7, A375, A549, HaCaT, and Jurkat cell lines. Compounds 8, 10, and 11 induced a dose-dependent reduction in cell viability with different potency on almost all cell lines used. The most active compounds, 8 and 10, were studied to assess their potential apoptotic effects and cell cycle inhibition.

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