2. Academic Validation
  3. Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

Functional Roles of Chemokine Receptor CCR2 and Its Ligands in Liver Disease

  • Front Immunol. 2022 Feb 25;13:812431. doi: 10.3389/fimmu.2022.812431.
Shaoping She 1,  Liying Ren 2,  Pu Chen 1,  Mingyang Wang 3,  Dongbo Chen 1,  Ying Wang 4,  Hongsong Chen 1
Affiliations

Affiliations

  • 1 Peking University Hepatology Institute, Beijing Key Laboratory of Hepatitis C and Immunotherapy for Liver Diseases, Peking University People's Hospital, Beijing, China.
  • 2 Laboratory of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, China.
  • 3 State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China.
  • 4 Department of Immunology, School of Basic Medical Sciences, and NHC Key Laboratory of Medical Immunology, Peking University, Beijing, China.
PMID: 35281057 DOI: 10.3389/fimmu.2022.812431
Abstract

Chemokines are a family of cytokines that orchestrate the migration and positioning of immune cells within tissues and are critical for the function of the immune system. CCR2 participates in liver pathology, including acute liver injury, chronic hepatitis, fibrosis/cirrhosis, and tumor progression, by mediating the recruitment of immune cells to inflammation and tumor sites. Although a variety of chemokines have been well studied in various diseases, there is no comprehensive review presenting the roles of all known chemokine ligands of CCR2 (CCL2, CCL7, CCL8, CCL12, CCL13, CCL16, and PSMP) in liver disease, and this review aims to fill this gap. The introduction of each chemokine includes its discovery, its corresponding chemotactic receptors, physiological functions and roles in inflammation and tumors, and its impact on different immune cell subgroups.

Keywords

CCL2; CCR2; PSMP; chemokine; hepatocellular carcinoma; macrophage.

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